Canadian Bio Med Systems, Inc., enters billion dollar market with two new Ophthalmic drugs.

New York, Montreal, San Diego California , February 11, 2009 – Canadian Bio Med Systems Inc., a subsidiary of ICBS Ltd., (OTCPK: ICBT),) , and Ocular Therapeutics Inc. of San Diego California, announced that it has acquired the licensing rights to two new potentially revolutionary drugs in the billion dollar ophthalmic arena .

The drug for the treatment of glaucoma is being developed by Daniel Stamer, PhD and Ronald Heimark, PhD at the University of Arizona. Glaucoma is a prevalent eye disease is one of the leading causes of blindness in the world. Patient compliance is a serious problem in glaucoma because of the frequency which conventional medication is required. The new drug being developed may change the paradigm of glaucoma therapy.

Eugene Levin, PhD at Torrey Pines in San Diego, California is developing the new drug for age-related macular degeneration (AMD). The protein in this compound is derived from a larger, naturally occurring human protein which will be used to control dangerous vessel growth in the retina at the very back of the eye. The new drug being developed is a much smaller protein than other AMD drugs being used today which means it may be used less frequently.

“We are very pleased that we have this agreement with Canadian Bio Med Systems, Inc. since it will allow for the development of these two very important products in two very important and sizable markets.” Said Richard H. Keates, MD, Chairman of Ocular Therapeutics, Inc. “The products being developed could make a considerable difference in the treatment of two of the most serious ophthalmic condition today.

Additional joint research is expected to commence in Canada under the direction of Dr. George Tsoukas of McGill University.

SOURCE: Ocular Therapeutics Inc.
CONTACT : Randy Bailey
TELEPHONE: 949- 228-4258
SOURCE: ICBS Limited www.icbs.ca

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Canadian Bio Med Systems Inc., Initiates Scientific Panel

NEW YORK, MONTREAL, SAN DIEGO, July 28 2009 /PRNewswire-FirstCall/ - Canadian Bio Med Systems Inc., a subsidiary of ICBS Ltd., (OTCPK: ICBT),) , and Ocular Therapeutics Inc., of San Diego California, announced today that Dr Jeffrey L. Olson, M.D. has joined the scientific panel of Canadian Bio Med Systems Inc.

Dr. Jeffrey Olson of the University of Colorado , a retinal surgeon, has become a member of (CBMS's) scientific board.

Dr. Olson is a member of the American Academy of Ophthalmology , the Association for Research in Vision and Ophthalmology and The American Society of Retinal Specialists. Dr. Olson has published numerous scientific papers and has been awarded grants from the National Institute of Health . Dr. Olson has participated in both pre-clinical and clinical studies for important retinal compounds.

Commenting on the Clinical Panel member, Dr. Richard H. Keates, Chairman of Ocular Therapeutics (CBMS), says "Dr. Olson is the perfect person to help direct our efforts in solving the problems of Age-related Macular degeneration. His experience with other projects such as this can help avoid pitfalls and speed this product to market successfully."

Age-Related Macular Degeneration (AMD) is the leading cause of blindness, worldwide, for people over 55 years of age. The incidence of AMD in persons aged 55 is 1% and increases to 15% for persons aged 80. This debilitating disease has proven to be difficult to treat and only a very few drugs have been developed which have positive effects.

The drug under development by Canadian Bio Med Systems , has a very different mode of action than the current therapeutic products. It can be used alone or in conjunction with these currently available products.

The product under development by CBMS, LD22-4 has the advantage of being a very small molecule meaning that fewer treatments will be needed compared to current therapies, This will help reduce the pain and frequency of injection to the patient and potentially the cost of the treatment.

Canadian Bio Med is developing the new product in Montreal in conjunction with its partner, Ocular Therapeutics Inc. of San Diego , California . The drug is moving toward human clinical trials in Canada and the United States next year.

The market for products treating AMD has been estimated at over $750 million annually and growing at a rate of over 10% yearly as the population ages.

NB. This news release includes statements that constitute forward-looking statements. Please be aware that any such forward-looking statements are not guarantees of future performance and involve significant risks and uncertainties, and that actual results may vary materially from those in the forward-looking statements as a result of any number of factors, including the risk factors contained in the Company's disclosure documents. back to top


Major Firms Eyeing CBMS Development of New Glaucoma Treatment

 New York, Montreal, San Diego California , July 7, 2009– Canadian Bio Med Systems Inc., a subsidiary of ICBS Ltd., (OTCPK: ICBT),) , and Ocular Therapeutics Inc. of San Diego California,  announced that Ocular Therapeutics has signed non-disclosure agreements with two of the largest pharmaceutical firms in the world.  These unnamed companies are interested in a new treatment approach in the largest of the ophthalmic markets.  

High Interest in a New Approach to Glaucoma Treatment  

One of the reasons these large entities are so interested in this project is because of a  recent article in the “Review of Ophthalmology” supports the development of a new class of glaucoma drugs now being tested by Canadian Bio Med Systems, Inc. (CBMS). The article was identified incorrectly as being from the “Survey of Ophthalmology” in an earlier release. The article entitled “Glaucoma Drugs: The Search for New Options” quotes David Epstein, MD, Chairman of Ophthalmology at Duke University School of Medicine in Durham North Carolina . Dr. Epstein points out that the approach of improving aqueous outflow in the eye is “the most logical approach to treating glaucoma”  

Glaucoma is caused by an increase of intraocular pressure within the eye. The new compound being developed by CBMS in conjunction with Ocular Therapeutics, Inc. of California , specifically targets a portion of the eye, Schlemm’s Canal, which is critical in achieving aqueous outflow and lowering intraocular pressure.  This novel approach to treatment may require application of the drug every three months, or even less often, rather that twice per day. It could revolutionize the treatment for glaucoma.  

Dr. Epstein points out the commercial aspects of such a potential drug that improves aqueous outflow by saying that when such a drug is developed “you will see every major pharmaceutical company jump on the bandwagon and want to have an outflow drug”. Further he says, “Then in retrospect, every one will say ‘Why didn’t we work on this drug sooner’”.  

CBMS is completing the studies required to enter into human clinical trials in centers both in the United States and Canada .

  The drug for the treatment of glaucoma is being developed by Daniel Stamer, PhD and Ronald Heimark, PhD at the University of Arizona . Glaucoma is a prevalent eye disease is one of the leading causes of blindness in the world. Patient compliance is a serious problem in glaucoma because  of the frequency which conventional medication is required. The new drug being developed may change the paradigm of glaucoma therapy.  back to top


Canadian Bio Med Attacks World’s Leading Cause of Blindness  

 New York, Montreal, San Diego California , June 30,2009 – Canadian Bio Med Systems Inc., a subsidiary of ICBS Ltd., (OTCPK: ICBT),) , and Ocular Therapeutics Inc. of San Diego California,  announced the development of  a new AMD drug now being tested by Canadian Bio Med Systems, Inc. (CBMS).  

Age-Related Macular Degeneration (AMD) is the leading cause of blindness, worldwide, for people over 55 years of age. The incidence of AMD in persons aged 55 is 1% and increases to 15% for persons aged 80. This debilitating disease has proven to be difficult to treat and only a very few drugs have been developed which have positive effects.  

The drug under development by Canadian Bio Med Systems ,  has a very different mode of action than the current therapeutic products. It can be used alone or in conjunction with these currently available products.  

The product under development by CBMS, LD22-4 has the advantage of being a very small molecule meaning that fewer treatments will be needed compared to current therapies, This will help reduce the pain and frequency of injection to the patient and potentially the cost of the treatment.  

Canadian Bio Med is developing the new product in Quebec in conjunction with its partner, Ocular Therapeutics Inc. of San Diego , California .  The drug is moving toward human clinical trials in Canada and the United States next year.  

The market for products treating AMD has been estimated at over $750 million annually and growing at a rate of over 10% yearly as the population ages. back to top


Journal Supports  New  Ophthalmic Drug being developed by Canadian Bio Med Systems , Inc.

 New York, Montreal, San Diego California , May 13, 2009 – Canadian Bio Med Systems Inc., a subsidiary of ICBS Ltd., (OTCPK: ICBT),) , and Ocular Therapeutics Inc. of San Diego California,  announced that  a recent article in the “Survey of Ophthalmology” supports the development of glaucoma drugs now being tested by Canadian Bio Med Systems, Inc. (CBMS). Journal Supports CBMS’s New Drug

The article entitled “Glaucoma Drugs: The Search for New Options” quotes David Epstein, MD, Chairman of Ophthalmology at Duke University School of Medicine in Durham North Carolina . Dr. Epstein points out that the approach of improving aqueous outflow in the eye is “the most logical approach to treating glaucoma”

 Glaucoma is caused by an increase of intraocular pressure within the eye. The new compound being developed by CBMS in conjunction with Ocular Therapeutics, Inc. of California , specifically targets a portion of the eye, Schlemm’s Canal, which is critical in achieving aqueous outflow and lowering intraocular pressure.  This novel approach to treatment may require application of the drug every three month rather that twice per day. It could revolutionize the treatment for glaucoma.

 Dr. Epstein points out the commercial aspects of such a potential drug that improves aqueous outflow by saying that when such a drug is developed “you will see every major pharmaceutical company jump on the bandwagon and want to have an outflow drug”. Further he says, “Then in retrospect, every one will say ‘Why didn’t we work on this drug sooner’”.

 CBMS is completing the studies required to enter into human clinical trials in centers both in the United States and Canada .

 The drug for the treatment of glaucoma is being developed by Daniel Stamer, PhD and Ronald Heimark, PhD at the University of Arizona . Glaucoma is a prevalent eye disease is one of the leading causes of blindness in the world. Patient compliance is a serious problem in glaucoma because  of the frequency which conventional medication is required. The new drug being developed may change the paradigm of glaucoma therapy.  back to top

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